Prothrombin-Sepharose-Purified Factor V and Its Role in Prothrombin Conversion
نویسندگان
چکیده
منابع مشابه
Frequency of factor V Leiden (G1691A) and prothrombin (G20210A) polymorphisms in Population of Kerman Province, Iran
Background & Aims:Thromboembolism is an acute cardiovascular disease that ranges from clinically unimportant to massive embolism. Both acquired and hereditary risk factors contribute to the disease. We aimed to determine the prevalence of two hereditary predisposing factor of the disease, prothrombin G20210A and factor V Leiden (G1691A) polymorphisms, in Kerman population.<br /...
متن کاملThe Association between Preeclampsia and Defined Polymorphisms in Prothrombin and Coagulation Factor V Genes
Background & Aims: Preeclampsia is one of the complications of pregnancy and a major cause of maternal mortality. Since, hypercoagulation is one of the risk factors, defined polymorphisms of V and II coagulation factors (G1691A and G20210A) may increase the risk of the disease. Methods: This investigation was performed on blood samp...
متن کاملFrequency of Factor V Leiden and Prothrombin Polymorphism in South of Iran
Normal hemostasis requires balanced regulation of prothrombotic and antithrombotic factors. Inherited alteration of factor V and prothrombin gene, the G20210A mutation, increases the resistance of factor V to degradation and booster production of prothrombin respectively. These alterations can increase hypercoagulability leading to thrombotic consequences. We aimed to assess the frequencies of ...
متن کاملFactor V Leiden, MTHFR C677T and Prothrombin Gene Mutation G20210A in Iranian Patients with Venous Thrombosis
Background: Factor V Leiden, Prothrombin gene (G20210A) and MTHFR (C677T) polymorphism are the main biomarkers for evaluation of tendency for venous thromboembolism. We aimed to investigate the frequency of mutations in factor V Leiden, Prothrombin G20210A and MTHFR C677T and identify the genetic status for these mutations in patients with venous thrombosis. Methods: This study was carried out...
متن کاملThe Conversion of Prothrombin to Thrombin V. THE ACTIVATION OF PROTHROMBIN BY FACTOR X, IN THE PRESENCE OF PHOSPHOLIPID*
The direct and concomitant formation of Intermediate 2 and Fragment 1.2 was demonstrated by activating prothrombin in the presence of iPrzP-F. In the absence of this inhibitor, thrombin, in addition to catalyzing the reaction of Equation 2, cleaves Fragment 1 from prothrombin and in so doing eliminates the possibility of observing phospholipid catalysis from all but the earliest stages of react...
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ژورنال
عنوان ژورنال: ASEAN Journal on Science and Technology for Development
سال: 2017
ISSN: 2224-9028,0217-5460
DOI: 10.29037/ajstd.221